Aplicación de la Hermenéutica Analógica al análisis de los modelos de enseñanza universitaria de enfermería / Analogical hermeneutic´s application to the analysis of teaching university models of nursing

En los últimos años se han producido cambios sociales que afectan a los profesionales de la educación. Estos cambios pueden poner en riesgo su calidad de vida profesional, personal y, por tanto, la calidad del sistema educativo. Esto nos lleva a estudiar qué le sucede al profesor. En este estudio centramos nuestra investigación en el docente universitario en ciencias de la salud. Para ello, mediante el análisis hermenéutico, basado en el triángulo actor-texto-lector, analizamos tres de los modelos conceptuales existentes en los docentes españoles: modelo presagio-proceso-producto, modelo mediacional y modelo personal. Tras este análisis concluimos que el modelo personal, a nuestro juicio, es el más adecuado para evaluar y analizar procesos existenciales, experimentales y vivenciales de la educación. Este modelo es el que nos aporta una mayor posibilidad hermenéutica, ya que es un modelo multidimensional y centra su interés en los elementos ontológicos y experienciales del proceso

There have been social changes affecting education professionals last years. These changes can reduce professional efficacy, personal accomplishment and therefore the quality education system. This leads us to study what happens to the professor. In this study we focused our research on university teacher in health sciences. We analyze three conceptual models: presage-process-product model, mediational model and personal model through a hermeneutical analyze based on actor-test-lector. We suggest the personal model to evaluate and analyze the existential, experimental and experientials processes of education. This one gives us a higher hermeneutical possibility since that it is a multidimensional model and it interest is focused on the ontological and experiential elements of the process

In vitro activity of the nonsteroidal anti-inflammatory drug indomethacin on a scuticociliate parasite of farmed turbot.

The scuticociliatosis produced by the endoparasite Philasterides dicentarchi is a severe parasitic infection of farmed turbot (Scophthalmus maximus) characterized by several histopathological effects including extensive inflammation. Indomethacin is a nonsteroidal anti-inflammatory drug that specifically inhibits synthesis of the proinflammatory mediator prostaglandins. The effect of indomethacin on the in vitro growth of P. dicentrarchi was investigated. In vitro growth of the scuticociliate was significantly inhibited by treatment with 100 microM indomethacin for 48 h. Higher concentrations of indomethacin (mM levels) did not affect the gelatinolytic activity of the cysteine proteinases of P. dicentrarchi. In vitro treatment with 25, 50 or 100 microM indomethacin for 3 days did not significantly affect the enzymatic activity of cysteine proteinases, as assayed with p-nitroanilide as substrate. Immunoblot analysis with anti-cysteine proteinase antibodies revealed an increase in proteinase expression (molecular weights of 80, 32 and 40-45 kDa) in parasite lysates originating from in vitro cultures incubated with 25 microM indomethacin for 72 h. Degradation of genomic DNA of the ciliates was observed in cultures incubated with 100 microM indomethacin for 1, 3 and 7 days. The results suggest that indomethacin is capable of inhibiting in vitro growth of the scuticociliate P. dicentrarchi by a mechanism related to the induction of programmed cell death, without affecting the enzymatic activation of parasite proteinases, which demonstrates the potential therapeutic use of this drug in the control of turbot scuticociliatosis.

Piperazine N-substituted naphthyridines, pyridothienopyrimidines and pyridothienotriazines: new antiprotozoals active against Philasterides dicentrarchi.

New antiprotozoals active against Philasterides dicentrarchi, the causative agent of scuticociliatosis in farmed turbot and Black Sea bass-bream, have been synthesised and tested. The most active compounds posses a piperazine ring, generally N-bonded to the heterocycle, and are the 1,8-naphthyridines, 2f and 5o, the pyridothienopyrimidine (7), and the pyridothienotriazines, 8, 9, 12d, 12f, 12h, 12m and 12k. Pyridothienotriazine (12k) presents the same activity (Lethal Dose, LD=0.8/1.5 mg L(-1)) as the well-known antiparasitics niclosamide and oxyclozanide.